The essays in this volume were written to celebrate the sixtieth birthday of G. E. L. Owen, who by his essays and seminars on ancient Greek philosophy has made a contribution to its study that is second to none.

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic and dizygotic twins, and the shared/unique contribution of genetic and environmental variance. Using linear mixed models, mental well-being was positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory, whereas depression and anxiety symptoms were (...) associated with poorer sustained attention, inhibition, cognitive flexibility and executive function. Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables. (shrink)

Traditionally clinicians have determined their patients' resuscitation status without consultation. This has been condemned as morally indefensible in cases where not for resuscitation (NFR) orders are based on quality of life considerations and when the patient's true wishes are not known. Such instances would encompass most resuscitation decisions in elderly patients. Having previously involved patients in CPR decision-making, we chose formally to explore the reasons behind the choices made. Although the patients were not upset, and readily decided at the time (...) of initial consultation, on later analysing the decision-making we found poor understanding of the procedure, poor recall of information given and in some cases evidence of harm. This may be attributed to impaired decision-making capacity of elderly hospitalised patients as previously shown, or to the discomfort precipitated by having to contemplate the apparent immediacy of cardiac arrest by these patients. We propose that subscribing to autonomy as a general principle needs to be balanced against particular cases where distress may be caused by, or result in, diminished competence and limited autonomy. (shrink)

In recent years a great deal of scholarly and philosophical discussion has been devoted to the interpretation and evaluation of the regress arguments which Parmenides is made to deploy against the theory of Ideas in the first part of the dialogue which takes its name from him. By contrast, scarcely anything has been written about the infinite regress argument which Parmenides presents at the start of the second of the deductions which make up the dialogue's second part. Yet while it (...) may contain less to reward the philosopher than the earlier regresses, it can hardly fail to perplex the scholar. (shrink)

Aristotle's Politics is widely recognized as one of the classics of the history of political philosophy, and like every other such masterpiece, it is a work about which there is deep division.

In lieu of an abstract, here is a brief excerpt of the content:Re-editing the RepublicMalcolm SchofieldS. R. Slings, ed. Platonis Respublica. Oxford Classical Texts. Oxford: Clarendon Press, 2003. xxiv + 428 pp. Cloth, $45.S. R. Slings' Republic is the second volume to appear in the new OCT edition of Plato. Reviewing the first—the new volume I, containing the first two tetralogies—Slings rounded off with some general remarks for the "average user of OCTs," who "will want to know to what degree (...) all this work has improved the text" (Mnemosyne 51 [1998] 101). If we apply the question to the fruits of his own tireless labours (the last of his seven general editorial principles is: editori non est fatiscendum), the answer is the same verdict as Slings passed on volume I: "The text is not all that different from Burnet's, and rightly so," for "he was a superb editor with a feeling for Platonic Greek that is unlikely to be ever surpassed" (ibid. 93). But did you know something Slings reports elsewhere (Mnem. 42 [1989] 192): that "when the volumes of Burnet's Platonis Opera first appeared, they were generally considered a provisional editio minor, soon to be superseded by more impressive tomes?" What is hugely improved is the apparatus criticus. There are two main reasons for this.First, Slings' text is based on a much more secure assessment of the textual tradition than was Burnet's, thanks not least to the comprehensive work of his former pupil Gerard Boter in The Textual Tradition of Plato's Republic (Leiden: Brill, 1989). Burnet gave pride of place to three primary witnesses: Parisinus 1807, ninth century (A); Marcianus 185, twelfth century (D); and Vindobonensis suppl. gr., dated by Slings to the period 1250-1325 (F). But he reported them selectively and sometimes inaccurately and never collated any of them himself. Moreover, while he was the first editor to recognise the true importance of the Vindobonensis, in Slings' opinion he accorded it more authority, particularly relative to the Parisinus, than it really carries. Finally, Burnet attached some weight to M, a manuscript in the library of the Malatestas at Cesena variously attributed to the twelfth, thirteenth, or fourteenth centuries (but considered fifteenth century by Slings and Boter) and collated for the Republic by Lewis Campbell. Boter's investigations have established that M carries no independent authority. Slings and Boter have reexamined all three of the primary medieval manuscripts both in photocopies and in situ, with what was evidently extreme care, and Slings says he has no doubt that the readings reported in the new OCT are a lot more reliable than in any previous edition. His general view of the [End Page 607] merits and demerits of A, D, and F—repeated here—was already set out in Appendix 2 to his major edition of the Clitophon (which precedes the Republic in the seventh tetralogy and shares its textual tradition); see Plato: Clitophon (Cambridge: Cambridge University Press, 1999) 340-44. Roughly speaking, A is the weightiest, D is of relatively minor importance, and F is "a typical representative of the cheap Plato omnibus as found in later antiquity," with "many uniquely true readings" but lots of errors and "untrustworthy variants in word order and particles" (ibid. 341).Second, as well as exploiting Plato papyri and translations into Coptic, Arabic, and Hebrew, Slings makes more generous use of the indirect tradition than do earlier editions by using quotations and allusions in subsequent ancient authors and scholia. He thanks a number of other Dutch scholars for their help in compiling this material and cites in particular Gerard Boter's index of testimonia in The Textual Tradition. Slings includes a list of those cited in his apparatus criticus as an appendix (it runs to seventeen pages). Moreover, interpretation of the information provided in the apparatus is aided by the clear explanation in the editor's pithy Latin preface of the rules and the orthographic practices he proposes to follow. In general, while Slings' apparatus is not consistently bulkier than Burnet's, it is often richer. Mostly this is thanks to better information about the textual tradition. But in line with the usual modern practice, Slings also gives the source of any Platonic quotation... (shrink)

For students and the general reader, this is the best English translation of the entire 'Laws' available. I give several examples of important lines that are translated well in this edition, but I take issue with the translation of some other lines and with part of Schofield's introduction on grounds that these parts do not reveal Plato's political and cosmic holism as clearly as they could have.

The clinical introduction of medical devices often occurs with relatively little oversight, regulation and (long-term) follow-up. Some recent controversies underscore the weaknesses of the current regime, such as the complications surrounding the metal-on-metal hip implants and the scandal surrounding the global breast implant scare of silicone implants made by France's Poly Implant Prothese (PIP) Company. The absence of national registries hampered the collection of reliable information on the risks and harms of the PIP breast implants. To warrant long-term safety, a (...) case can be made for mandatory post-marketing surveillance by means of the establishment of compulsory registries. In this edition of Public Health Ethics, Schofield calls for debate on how such a registry system should be initiated and maintained and how it would relate to the ethical requirement of consent. Here we use breast implant registries as a case to discuss whether and when a so-called ‘thick opt-out’ would be an appropriate method to include people in medical device registries. We conclude that a thick opt-out procedure for medical device registries is only justifiable in cases where inclusion does not involve burdens (or very low), when it does not involve a sensitive subject and when the data are stored anonymously (or at least not directly linked to the medical record). Otherwise, inclusion should be sought by means of an opt-in. (shrink)